The Leaky Gut-Progesterone Link: How Zonulin and LPS Disrupt Hormone Balance
Introduction When it comes to hormone balance, most people focus on the ovaries, adrenals, or thyroid—but what about the gut? Research now shows that intestinal permeability (leaky gut) plays a direct role in progesterone depletion , thanks to inflammatory molecules like zonulin and lipopolysaccharides (LPS) . This gut-hormone link explains why so many women struggling with irregular cycles, PMS, and low progesterone may actually need to heal their gut first. In this article, we'll explore the fascinating connection between gut health and hormone balance. Specifically, we'll examine how two key factors— zonulin (a protein that regulates gut permeability) and lipopolysaccharides (LPS) (bacterial toxins)—create a vicious cycle that depletes progesterone. We'll also discuss the best tests to assess gut and hormone health and a natural protocol to restore balance. Whether you're struggling with irregular cycles, mood swings, fertility challenges, or unexplained ...
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